A fundamental challenge in preclinical research is accurately predicting human responses using conventional animal models. Traditional approaches often fail to adequately model human disease, creating ...

Humanized immune system (HIS) mice provide researchers with a unique opportunity to study human immune responses in a living organism. Developed to address the lack of suitable in vivo models for ...

Understanding human gene function in living organisms has long been hampered by fundamental differences between species. Although mice share most protein-coding genes with humans, their regulatory ...