Nature

Potentiation of oncolytic adenoviral vector efficacy with gutless vectors encoding GMCSF or TRAIL

The development of gene therapies for the treatment of cancer has generally relied upon two strategies. The first is the expression of a therapeutic transgene from a replication-defective (RD) viral ...
Nature

A lentiviral vector encoding the human Wiskott–Aldrich syndrome protein corrects immune and cytoskeletal defects in WASP knockout mice

The life expectancy of WAS patients is limited and death occurs after bleeding, recurrent infections or malignancies. At present, WAS patients can be kept alive for over 10 years by conventional ...
Seeking Alpha

EsoBiotec to Present Preclinical Proof-of-Concept Data for Its Off-the-Shelf ENaBL In Vivo Cell Therapy Platform at the 28th Annual Meeting of the American Society of Gene and ...

Poster talk will present safety and efficacy data for ENaBL-T, a lentiviral vector for in vivo engineering of BCMA CAR T cells, which supported the first in vivo BCMA CAR-T cell therapy clinical trial ...