Three independent studies describe the crystal structure of complement component 3b (C3b), which is derived from the proteolytic activation of C3, and reveal that conformational rearrangements ...

We have also determined and refined a structure of C3b in another crystal form, with a shorter c-axis, which reveals direct crystal contacts between C3b molecules. Notably, the rest of the structure ...

PHILADELPHIA - A team from the University of Pennsylvania School of Medicine and Utrecht University has deciphered a key step in an evolutionarily old branch of the immune response. This system, ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 24 (Jun. 15, 2004), pp. 8924-8929 (6 pages) Vaccinia virus complement control protein (VCP), a homolog of ...

In the alternative pathway, C3b binds to Factor B. Factor D releases Factor Ba from Factor B bound to C3b. The complex of C3b (2)Bb is a protease which cleaves C5 into C5b and C5a. C5 convertase is ...

Reviews of Infectious Diseases, Vol. 5, Supplement 4. Bacterial Virulence and Pathogenicity (Sep. - Oct., 1983), pp. S797-S805 (9 pages) An experimental model of pneumococcal bacteremia in guinea pigs ...

Please provide your email address to receive an email when new articles are posted on . In a first-in-human phase 1/2 study, GT005, an AAV2-based one-time investigational gene therapy, showed ...

The complement receptor 1 (CR1) gene encodes a transmembrane glycoprotein that functions in the innate immune system. CR1 is expressed on blood cells and microglia. As a receptor for the complement ...

The complement system has an important role in neuroinflammation, both in the pathogenesis of Alzheimer’s disease and in the most severe infections affecting the central nervous system such as ...

The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by ...