For the complement system to cause AMD, there must be initiation (a ‘trigger’), amplification, and local retinal damage caused by the process. The alternative pathway of the complement system is ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, No. 8 (Apr. 15, 1987), pp. 2459-2463 (5 pages) The human C3b/C4b receptor (Cr1) is a Mr≈ 200,000 single-chain ...
Two functions have been assigned to properdin; stabilization of the alternative convertase, C3bBb, is well accepted, whereas the role of properdin as pattern recognition molecule is controversial. The ...
The complement receptor 1 (CR1) gene encodes a transmembrane glycoprotein that functions in the innate immune system. CR1 is expressed on blood cells and microglia. As a receptor for the complement ...
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